| Career - Innings Pitched | |||
| Rk | Player Name | Totals | |
| 1 | Tim Hudson | 2040.6 | |
| 2 | David Price | 1877.1 | |
| 3 | John Smoltz | 1826.1 | |
| 4 | Steve Avery | 1383.0 | |
| 5 | Kenny Rogers | 1365.6 | |
| 6 | Bret Saberhagen | 1289.7 | |
| 7 | C.C. Sabathia | 1028.2 | |
| 8 | Kerry Wood | 882.8 | |
| 9 | Mark Clark | 833.3 | |
| 10 | Doug Fister | 815.3 | |
| 11 | Jair Jurrjens | 788.7 | |
| 12 | Odalis Perez | 674.1 | |
| 13 | Craig Kimbrel | 613.5 | |
| 14 | Marco Estrada | 593.1 | |
| 15 | Trevor Bauer | 517.5 | |
| 16 | Huston Street | 505.1 | |
| 17 | Jack Flaherty | 497.6 | |
| 18 | Bobby Ojeda | 490.0 | |
| 19 | Bailey Ober | 467.0 | |
| 20 | Chris Tillman | 431.2 | |
| 21 | Joe Ryan | 414.0 | |
| 22 | Jimmy Key | 409.5 | |
| 23 | Trevor Hoffman | 405.8 | |
| 24 | Keith Foulke | 399.3 | |
| 25 | Pedro Martinez | 394.8 | |
| Single Season - Innings Pitched | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Matt Young | 321.7 | 1991 | ||
| 2 | Jack Armstrong | 314.0 | 1991 | ||
| 3 | Steve Avery | 274.7 | 1993 | ||
| 4 | Steve Avery | 266.0 | 1994 | ||
| 5 | Bret Saberhagen | 256.7 | 1992 | ||
| 6 | Bret Saberhagen | 251.7 | 1995 | ||
| 7 | David Price | 250.0 | 2013 | ||
| 8 | John Smoltz | 249.2 | 1998 | ||
| 9 | Kenny Rogers | 248.2 | 1999 | ||
| 10 | C.C. Sabathia | 248.0 | 2008 | ||
| 11 | Tim Hudson | 247.0 | 2004 | ||
| 12 | Mark Clark | 245.2 | 1999 | ||
| 13 | Tim Hudson | 241.3 | 2003 | ||
| 14 | John Smoltz | 239.0 | 2000 | ||
| 15 | Doug Fister | 237.0 | 2013 | ||
| 16 | Bret Saberhagen | 234.3 | 1994 | ||
| 17 | Bobby Ojeda | 233.7 | 1993 | ||
| 18 | Bret Saberhagen | 232.7 | 1993 | ||
| 19 | Josh Tomlin | 232.2 | 2016 | ||
| 20 | Jake Westbrook | 232.0 | 2009 | ||
| 21 | John Smoltz | 230.0 | 2006 | ||
| 22 | John Smoltz | 230.0 | 2007 | ||
| 23 | Pedro Martinez | 228.0 | 2006 | ||
| 24 | Esteban Loaiza | 227.0 | 2004 | ||
| 25 | Mark Clark | 225.1 | 1998 | ||