| Career - ERA | |||
| Rk | Player Name | Totals | |
| 1 | Kyle Hendricks | 2.97 | |
| 2 | Jarred Cosart | 3.13 | |
| 3 | Eduardo Rodriguez | 3.52 | |
| 4 | Luis Castillo | 3.52 | |
| 5 | Aaron Nola | 3.63 | |
| 6 | Jordan Montgomery | 3.68 | |
| 7 | Charlie Morton | 4.18 | |
| Single Season - ERA | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Kyle Hendricks | 2.03 | 2015 | ||
| 2 | Eduardo Rodriguez | 2.38 | 2019 | ||
| 3 | Eduardo Rodriguez | 2.56 | 2016 | ||
| 4 | Luis Castillo | 2.64 | 2020 | ||
| 5 | Jarred Cosart | 2.66 | 2015 | ||
| 6 | Aaron Nola | 2.91 | 2019 | ||
| 7 | Luis Castillo | 3.00 | 2023 | ||
| 8 | Aaron Nola | 3.00 | 2018 | ||
| 9 | Charlie Morton | 3.05 | 2020 | ||
| 10 | Luis Castillo | 3.12 | 2018 | ||
| 11 | Aaron Nola | 3.18 | 2021 | ||
| 12 | Jordan Montgomery | 3.27 | 2024 | ||
| 13 | Aaron Nola | 3.28 | 2023 | ||
| 14 | Luis Castillo | 3.41 | 2021 | ||
| 15 | Charlie Morton | 3.52 | 2022 | ||
| 16 | Adam Conley | 3.55 | 2016 | ||
| 17 | Ivan Nova | 3.55 | 2018 | ||
| 18 | Aaron Nola | 3.57 | 2020 | ||
| 19 | Jarred Cosart | 3.61 | 2014 | ||
| 20 | Noah Syndergaard | 3.67 | 2023 | ||
| 21 | Deivi Garcia | 3.68 | 2021 | ||
| 22 | Charlie Morton | 3.69 | 2024 | ||
| 23 | Brayan Bello | 3.79 | 2024 | ||
| 24 | Jordan Montgomery | 3.81 | 2022 | ||
| 25 | Luis Castillo | 3.93 | 2019 | ||