| Career - Earned Runs | |||
| Rk | Player Name | Totals | |
| 1 | Jake Odorizzi | 635 | |
| 2 | Jake Arrieta | 484 | |
| 3 | Zac Gallen | 435 | |
| 4 | Dylan Cease | 392 | |
| 5 | Carlos Martinez | 388 | |
| 6 | Patrick Corbin | 351 | |
| 7 | Luke Weaver | 290 | |
| 8 | Clayton Kershaw | 219 | |
| 9 | Dakota Hudson | 212 | |
| 10 | Andrew Heaney | 185 | |
| 11 | Ross Stripling | 157 | |
| 12 | Luis Garcia | 156 | |
| 13 | Taylor Rogers | 150 | |
| 14 | Paul Sewald | 143 | |
| 15 | Alek Manoah | 143 | |
| 16 | Nestor Cortes | 140 | |
| 17 | A.J. Griffin | 120 | |
| 18 | Ian Kennedy | 115 | |
| 19 | Gavin Williams | 115 | |
| 20 | Shelby Miller | 109 | |
| 21 | Luis H. Garcia | 109 | |
| 22 | Mark Buehrle | 108 | |
| 23 | Dustin May | 103 | |
| 24 | Drew Hutchison | 100 | |
| 25 | Andres Munoz | 98 | |
| Single Season - Earned Runs | |||||
| Rk | Player Name | Totals | Year | ||
| 1 | Jake Arrieta | 133 | 2018 | ||
| 2 | Jake Odorizzi | 131 | 2018 | ||
| 3 | Carlos Martinez | 126 | 2018 | ||
| 4 | A.J. Griffin | 120 | 2014 | ||
| 5 | Ian Kennedy | 115 | 2014 | ||
| 6 | Dakota Hudson | 115 | 2020 | ||
| 7 | Gavin Williams | 115 | 2024 | ||
| 8 | Dylan Cease | 112 | 2024 | ||
| 9 | Shelby Miller | 109 | 2015 | ||
| 10 | Luis H. Garcia | 109 | 2024 | ||
| 11 | Mark Buehrle | 108 | 2014 | ||
| 12 | Jake Odorizzi | 107 | 2020 | ||
| 13 | Carlos Martinez | 105 | 2016 | ||
| 14 | Zac Gallen | 105 | 2022 | ||
| 15 | Jake Arrieta | 103 | 2019 | ||
| 16 | Patrick Corbin | 102 | 2020 | ||
| 17 | Drew Hutchison | 100 | 2015 | ||
| 18 | Dylan Cease | 99 | 2021 | ||
| 19 | Luis Garcia | 95 | 2023 | ||
| 20 | Nestor Cortes | 93 | 2022 | ||
| 21 | Clayton Kershaw | 91 | 2016 | ||
| 22 | Patrick Corbin | 91 | 2019 | ||
| 23 | Jake Odorizzi | 90 | 2017 | ||
| 24 | Garrett Whitlock | 90 | 2024 | ||
| 25 | Andrew Heaney | 89 | 2016 | ||